ea0098b15 | Basic Science | NANETS2023
Tow Dane H.
, Ridder Maclain
, Tran Catherine G.
, Borbon Luis C.
, Li Guiying
, Kaemmer Courtney A.
, Abusada Ellen
, Harish Mahalingam Aswanth
, Sadanandam Anguraj
, Chandrasekharan Chandrikha
, Dillon Joseph
, Spitz Douglas R.
, Quelle Dawn E.
, H.F. Chan Carlos
, Bellizzi Andrew
, Howe James R.
, Po Hien Ear and
Background: Small bowel neuroendocrine tumors (SBNETs) originate from enterochromaffin cells in the intestine which synthesize and secrete serotonin. Other NETs and other cancers may also produce serotonin but do not store them in vesicles. The rate limiting enzyme of serotonin biosynthesis is tryptophan hydroxylase 1 (Tph1). Patients with high serotonin level could develop carcinoid syndrome, which can be treated with somatostatin analogues and the Tph1 inhibitor telotristat ...